| Name | Year in Greenwood | Major League Team |
|---|---|---|
| Orth Collins | 1911 | Yankees, Senators |
| Rebel Oaks | 1921 | Reds, Cardinals, Pittsburgh Rebels(FL) |
| Sam Vick | 1922 | Yankees, RedSox |
| Dino Chiozza | 1936 | Phillies |
| Frank Brazil | 1936-1937 | A's |
| Elmer Yoter | 1938 | A's, Indians, Cubs |
| Gerard Lipscomb | 1939-1940 | Browns |
| Walter Carson | 1940 | Indians |
| Jim Bivin | 1947-1949 | Phillies |
| Lou Rochelli | 1950-1951 | Dodgers |
Perhaps the two most famous former Greenwood players were Walter Alston and Hughie Critz. Alston played his first professional season in Greenwood in 1935 and was promoted to the parent St. Louis Cardinals for the 1936 season, where he struck out in the only at bat of his major league career. He was manager of the Brooklyn and Los Angeles Dodgers for 23 seasons and was elected to the Baseball Hall of Fame in 1983.
Critz played for Greenwood in 1920 and 1921, and after seasons in Memphis and Minneapolis, he was sold to the Reds for the 1924 season. He played there until he was traded to the New York Giants in 1930. Critz starred at 2B until he retired following the 1935 season. He played for the 1933 World Champion New York Giants.